INSPIRE Lab Imaging- and Neuro-computations for Precision Informatics Research

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2025

QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity
QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity
Nan Xu, Behnaz Yousefi, Nmachi Anumba, Theodore J. LaGrow, Xiaodi Zhang, Shella Keilholz
SoftwareX  ·  01 Feb 2025  · doi:10.1016/j.softx.2025.102067

2024

Variation in the distribution of large-scale spatiotemporal patterns of activity across brain states
Variation in the distribution of large-scale spatiotemporal patterns of activity across brain states
Lisa Meyer-Baese, Nmachi Anumba, T. Bolt, L. Daley, T. J. LaGrow, Xiaodi Zhang, Nan Xu, Wen-Ju Pan, E. H. Schumacher, Shella Keilholz
Frontiers in Systems Neuroscience  ·  02 Aug 2024  · doi:10.3389/fnsys.2024.1425491
Time-varying causal interactions in the functional brain networks: Modeling and Validation
Time-varying causal interactions in the functional brain networks: Modeling and Validation
Nan Xu, Xiaodi Zhang, Wenju Pan, Jeremy L. Smith, Jason W. Allen, Vince D. Calhoun, Shella D. Keilholz
Organization for Human Brain Mapping 2024 Annual Meeting  ·  23 Jun 2024
The effects of locus coeruleus stimulation on quasi-periodic patterns in rats
The effects of locus coeruleus stimulation on quasi-periodic patterns in rats
Nmachi Anumba, Michael A. Keilberman, Wenju Pan, Alexia Marriott, Nan Xu, David Weinshenker, Shella Keilholz
Organization for Human Brain Mapping 2024 Annual Meeting  ·  23 Jun 2024
Modeling and Validation of Dynamic Causal Interactions in Functional Brain Network
Modeling and Validation of Dynamic Causal Interactions in Functional Brain Network
Nan Xu, Xiaodi Zhang, Wenju Pan, Jeremy L. Smith, Jason W. Allen, Vince D. Calhoun, Shella D. Keilholz
10th Annual BRAIN Initiative Conference  ·  18 Jun 2024
Time-varying functional connectivity predicts fluctuations in sustained attention in a serial tapping task
Time-varying functional connectivity predicts fluctuations in sustained attention in a serial tapping task
Dolly T. Seeburger, Nan Xu, Marcus Ma, Sam Larson, Christine Godwin, Shella D. Keilholz, Eric H. Schumacher
Cognitive, Affective, & Behavioral Neuroscience  ·  22 Jan 2024  · doi:10.3758/s13415-024-01156-1
The effects of locus coeruleus optogenetic stimulation on global
                    spatiotemporal patterns in rats
The effects of locus coeruleus optogenetic stimulation on global spatiotemporal patterns in rats
Nmachi Anumba, Michael A. Kelberman, Wenju Pan, Alexia Marriott, Xiaodi Zhang, Nan Xu, David Weinshenker, Shella Keilholz
Imaging Neuroscience  ·  01 Jan 2024  · doi:10.1162/imag_a_00314

2023

``Hyperconnected'' Vestibular State in Subacute and Chronic Post-Concussive Vestibular Dysfunction Using Dynamic Whole Brain Functional Connectivity Analysis
``Hyperconnected'' Vestibular State in Subacute and Chronic Post-Concussive Vestibular Dysfunction Using Dynamic Whole Brain Functional Connectivity Analysis
Anna Trofimova, Jeremy Smith, Nan Xu, Shella Keilholz, Russell Gore, Jason W. Allen
The 16th Annual Meeting of the American Society of Functional Neuroradiology  ·  07 Oct 2023
Oral Presentation.
Spatial and Spectral Components of the <scp>BOLD</scp> Global Signal in Rat <scp>Resting‐State</scp> Functional <scp>MRI</scp>
Spatial and Spectral Components of the BOLD Global Signal in Rat Resting‐State Functional MRI
Nmachi Anumba, Eric Maltbie, Wen‐Ju Pan, Theodore J. LaGrow, Nan Xu, Shella Keilholz
Magnetic Resonance in Medicine  ·  15 Aug 2023  · doi:10.1002/mrm.29824
The interaction between random and systematic visual stimulation and
                    infraslow quasi-periodic spatiotemporal patterns of whole-brain
                    activity
The interaction between random and systematic visual stimulation and infraslow quasi-periodic spatiotemporal patterns of whole-brain activity
Nan Xu, Derek M. Smith, George Jeno, Dolly T. Seeburger, Eric H. Schumacher, Shella D. Keilholz
Imaging Neuroscience  ·  01 Aug 2023  · doi:10.1162/imag_a_00002
Employed the statistical inferences techniques to study the interplay between infraslow dynamic processes and visual perceptions. Discovered that these intrinsic dynamic processes are notably resilient in humans, as contrast with anesthetized rodents (Belloy et al., 2021). Yet, their stability can still be affected in diverse ways: they can swamp an overlapping BOLD response evoked by the flickering checkerboard, but their phase-locked waveform can still be modulated by different sequences of stimuli that affects the reaction time and sustained attention.
The interaction between visual stimulation and intrinsic infraslow whole brain activity in humans
The interaction between visual stimulation and intrinsic infraslow whole brain activity in humans
Nan Xu, Derek Smith, George Geno, Dolly T. Seeburger, Eric H. Schumacher, Shella D. Keilholz
Organization for Human Brain Mapping 2023 Annual Meeting  ·  22 Jul 2023
Distribution of large-scale spatiotemporal patterns within and across individuals
Distribution of large-scale spatiotemporal patterns within and across individuals
Taylor Bolt, Nan Xu, Laren Daley, T.J. LaGrow, W-J Pan, Eric Schumacher, Shella Keilholz
Organization for Human Brain Mapping 2023 Annual Meeting  ·  22 Jul 2023

2022

Identifying the neural mechanisms of zone state performance using time-varying functional connectivity methods.
Identifying the neural mechanisms of zone state performance using time-varying functional connectivity methods.
Dolly T. Seeburger, Nan Xu, C Godwin, Marcus Ma, Shella D. Keilholz, Eric H. Schumacher
Cognitive Neuroscience Society 2022 Annual Meeting  ·  23 Apr 2022
Oral Presentation.
Investigating the relationship between sustained attention and quasi-periodic brain activity patterns with the psychomotor vigilance task.
Investigating the relationship between sustained attention and quasi-periodic brain activity patterns with the psychomotor vigilance task.
Yunji Lee, Dolly T. Seeburger, Sakshi Dhawan, Tiffany Nguyen, Nan Xu, …, Anzar Abbas, Waqas Majeed, Garth Thompson, Shella D. Keilholz, Eric H. Schumacher
Cognitive Neuroscience Society 2022 Annual Meeting  ·  23 Apr 2022
Functional Connectivity of the Brain Across Rodents and Humans
Functional Connectivity of the Brain Across Rodents and Humans
Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Azalea Lee, Xiaodi Zhang, …, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati, Wen-Ju Pan, Shella Keilholz
Frontiers in Neuroscience  ·  08 Mar 2022  · doi:10.3389/fnins.2022.816331

2021

Quasiperiodic patterns and BOLD response entrained by visual stimulation in the human brain.
Quasiperiodic patterns and BOLD response entrained by visual stimulation in the human brain.
Nan Xu, Derek M. Smith, George Jeno, Dolly T. Seeburger, Eric H. Schumacher, Shella D. Keilholz
Organization for Human Brain Mapping 2021 Annual Meeting  ·  30 May 2021

2020

Relationship Between Basic Properties of BOLD Fluctuations and Calculated Metrics of Complexity in the Human Connectome Project
Relationship Between Basic Properties of BOLD Fluctuations and Calculated Metrics of Complexity in the Human Connectome Project
Shella Keilholz, Eric Maltbie, Xiaodi Zhang, Behnaz Yousefi, Wen-Ju Pan, Nan Xu, Maysam Nezafati, Theodore J. LaGrow, Ying Guo
Frontiers in Neuroscience  ·  15 Sep 2020  · doi:10.3389/fnins.2020.550923

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